It is well known that undesirable isolated concentrations of contrast material can cause obscurity when physicians attempt diagnoses. Misinterpretation of artifacts and confusion between normal enhancing structures and tumors were found to be two of the most common reasons for errant false-positive findings [9,10]. Familiarity of artifacts and their sources is extremely important in order to learn how to eliminate them [11]. The usefulness of vascular access ports to assist imaging needs has been limited by the lack of thorough testing and evaluation as it relates to contrast injection. Here, we have demonstrated that there can be success in the administration of injectable gadolinium contrast directly in the port septum for MRI diagnostic imaging. The study was thorough in examining various port types by construction design and composition. Repeated succinct testing verified that retention of contract is a concern if there is no accompanying flush to remove it from the port afterward. Still, the investigation revealed no difficulty in any port model to eradicate 99% or more of the injected gadolinium concentration with only one 10 mL saline injection.It should be noted that we have examined only a few types of vascular access ports. Although many ports used clinically today involve similar materials and similar shapes as the ones tested in this study, the reader is cautioned that there can be differences in retention for other makes and models when used with gadolinium injection. Additionally, it is not recommended that the user extrapolate or expect identical results when ports are injected with other contrast agents.