Figure 4: Immunohistochemical staining showing the significant increase of elastic fibers after the cosmetic treatment (b) compared to pretreatment (a). Immunohistochemical staining showing the expression of collagen III before (c) and after treatment showing a significant increase of this ECM marker (d). Immunohistochemical staining for fibronectin showing its expression before treatment (e) and the important increase after the cosmetic treatment (f) (40x magnification).