FOG may become the most disabling symptom which force the patient to stay at home or use a wheelchair. The basic mechanism responsible for FOG is unclear. Disease progression by itself is playing an important role as shown in the DATATOP study (Giladi et al., 1996) but clearly dopaminergic, therapies are playing an important role (Ambani and Van Woert, 1973; Barbeau,1972, 1976).