EthyleneOxideSterilizationSterilization occurs when a chamber holding the implants at 30 to 50 ̊C is first evacuated, then flooded with EtO, and finally purged several times with air. Following this, further aeration outside the sterilizer aids in removal of any remaining EtO.– EtO causes pathogen death primarily through permanent, chemical alteration of nucleic acids (DNA, RNA).– It is effective, even deep within crevices or pores, and, because it is carried out at a low temperature, it can be used for a wide variety of materials.– toxic resides of EtO that may be left in the device are of great concern. (possible carcinogenic nature)