To promote appropriate
immune responses in the gut, complex networks of
specialised cells have evolved that act within the lamina
propria and gut associated lymphoid tissue (GALT). Within
the GALT, cryptopatches (CP), isolated lymphoid follicles
(ILFs), aggregated lymphoid follicles [such as Peyer’s
patches (PPs)] and ILF-like tertiary lymphoid tissue (TLT)
can be distinguished based on differences in cellular composition,
genetically predetermined developmental factors,
as well as dependence on environmental triggers and
response during tissue inflammation [3].