Groups of 40 rats (equally divided by sex) were maintained on
diets containing 0 or 5% sodium alginate for a period of two years.
During this period approximately half the rats were bred once to
produce an F1-generation, which was subsequently bred to produce
an F2-generation. There were no significant differences in growth
rate of test groups and controls, for either the parent group over
the two-year period or the progeny (F1 and F2). Reproductive
performance was normal. Haematological values of the parent group,
as well as those of the F2 offspring, were normal. Gross and
microscopic study of various tissues and organs of the parent groups
at two years, and of the F1 and F2 groups at the conclusion of
the rapid growth period, were normal (Morgan et al., undated).