Specifically, the optimized AuAg3.2 NS catalyst delivers exceptional performance for ORR with specific activity (SA) and mass activity (MA) of 1.36 mA cm−2 and 1.26 A mgAu−1 at 0.85 V, respectively, about 6.7 and 8.2 times higher than that of commercial Pt/C, respectively, making the Au−Ag NSs the most active catalyst among the current Au−Ag systems for ORR.