ΔNp63α expression can be
induced in isolated dental epithelia from E11-E14 mice
by beads releasing BMP2, BMP7, and FGF10.Also during development, ΔNp63α expression in the
mouse lamboidal junction, a developmental feature during
facial morphogenesis, has been shown to be under
the control of Wnt9b signaling via an intronic Lef-Tcf
binding element on the mouse Trp63 gene locus that is
highly conserved in mammals. Of note, BMP and
Wnt signaling are crucial for normal epidermal and
ectodermal appendage development