Preparation and characterization of

Preparation and characterization of coaxial electrospun thermoplastic polyurethane/collagen compound nanofibers for tissue engineering applications.
Collagen functionalized thermoplastic polyurethane nanofibers (TPU/collagen) were successfully produced by coaxial electrospinning technique with a goal to develop biomedical scaffold. A series of tests were conducted to characterize the compound nanofiber and its membrane in this study. Surface morphology and interior structure of the ultrafine fibers were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and atomic force microscopy (AFM), whereas the fiber diameter distribution was also measured. The crosslinked membranes were also characterized by SEM. Porosities of different kinds of electrospun mats were determined. The surface chemistry and chemical composition of collagen/TPU coaxial nanofibrous membranes were verified by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectrometry (FTIR). Mechanical measurements were carried out by applying tensile test loads to samples which were prepared from electrospun ultra fine non-woven fiber mats. The coaxial electrospun nanofibers were further investigated as a promising scaffold for PIECs culture. The results demonstrated that coaxial electrospun composite nanofibers had the characters of native extracellular matrix and may be used effectively as an alternative material for tissue engineering and functional biomaterials.

結果 (中文) 1:

同轴电纺热塑性聚氨酯/胶原的制备与表征复合纳米纤维组织工程应用。胶原羧基热塑性聚氨酯纳米纤维 (TPU/胶原质) 成功是由同一个目标，发展生物医学脚手架同轴静电纺丝技术生产的。一系列的测试进行复合纳米纤维和其在这项研究的膜进行了表征。表面形貌和超细纤维的内部结构进行了表征通过扫描电子显微镜 (SEM)、 透射电镜 (TEM) 和原子力显微镜 (AFM)，而也测量纤维直径分布。还有一个特点交联膜镜孔隙度不同种类的静电纺丝垫进行了测定。通过 x 射线光电子能谱 (XPS) 和傅里叶变换红外光谱法 (FTIR) 验证的表面化学和胶原/TPU 同轴纳米纤维膜的化学组成。通过将拉伸试验荷载应用于静电纺超细纤维非织造布垫法制备的样品进行了机械测量。为有前途的支架材料的 PIECs 文化进一步研究了同轴电纺纳米纤维。结果表明，同轴电纺复合纳米纤维原细胞外基质的字符可能有效地用作组织工程和功能性生物材料替代材料。

結果 (中文) 3:

同轴静电纺丝和热塑性聚氨酯/胶原组织工程应用的复合纳米纤维的制备。
胶原纤维功能化的热塑性聚氨酯（TPU /胶原）是由具有目标发展生物医学支架同轴静电纺丝技术成功地制备了。一系列的测试进行了表征复合纳米纤维及其在本研究膜。用扫描电镜、透射电镜和原子力显微镜对超细纤维的表面形貌和内部结构进行了表征，同时测定了纤维的直径分布。并用扫描电镜对交联膜进行了表征。测定了不同种类的电纺纤维膜的孔隙率。胶原/ TPU的X射线光电子能谱证实同轴纳米纤维膜表面的化学组成和化学（XPS）和傅里叶变换红外光谱（FTIR）。机械测量采用拉伸试验荷载对样品进行电纺超细纤维无纺布的制备进行。进一步研究作为文化的一种很有前途的PIECs同轴静电纺丝纳米纤维支架进行。结果表明，同轴电纺复合纳米纤维具有天然细胞外基质的特点，可以有效地用来作为组织工程和生物功能材料替代材料。