This study contributes to the under

This study contributes to the understanding of the IGF system and its regulation in cats. Total IGF‐I concentrations in serum were positively associated with the amount of IGF binding in a 150kDa TC, with lower IGF‐I levels associated with relatively more binary IGF‐IGFBP complexes. Furthermore, IGF‐I concentrations were increased at 2–4 weeks after initiation of insulin treatment and higher IGF‐I concentrations at this time‐point were associated with remission from DM. An increase in circulating IGF‐I with treatment was accompanied by a shift to increased amounts of TC compared with binding in lower molecular mass binary complexes. Consistent with this shift, IGFBP‐3 concentrations were also observed to increase. It is therefore recommended that, when using IGF‐I as a marker of GH status in cats with diabetes, the effect of insulin treatment on IGF‐I should be taken into account.

結果 (繁體中文) 1:

這項研究有助於IGF系統的認識及其在貓調控。在血清總IGF-I的濃度呈正IGF的在150kDa TC結合，與具有相對多個二進制IGF-IGFBP複合物相關聯的低IGF-I水平的量相關聯。此外，IGF-I濃度分別固定在2-4週胰島素治療和更高的IGF-I濃度的開始後在該時間點增加用來自DM緩解相關聯。在循環IGF-I治療伴隨著換檔到TC的量增加的增加與低分子量二元複合物的結合進行比較。與此移相一致，IGFBP-3的濃度也觀察到增加。因此，建議在使用時，IGF-1，為的GH狀態貓患有​​糖尿病的標誌，

結果 (繁體中文) 2:

這項研究有助於瞭解IGF系統及其在貓身上的調節。血清中IGF+I總濃度與150kDa TC中的IGF結合量呈正相關，IGF-I水準較低，與相對較多的二元IGF_IGFBP複合物相關。此外，IGF+I濃度在開始胰島素治療後2~4周增加，此時IGF-I濃度較高與DM緩解有關。與低分子品質二元複合物結合相比，隨著治療的迴圈IGF_I的增加，隨著TC量的增加而發生轉變。與這一變化一致，IGFBP+3濃度也觀察到增加。因此，建議在使用IGF+I作為糖尿病貓GH狀態的標誌時，應考慮胰島素治療對IGF_I的影響。

結果 (繁體中文) 3:

本研究有助於瞭解猫胰島素樣生長因數系統及其調控。血清總IGF-I濃度與150kDa TC中IGF結合量呈正相關，較低的IGF-I水准與相對較多的二元IGF-IGFBP複合物相關。此外，胰島素治療開始後2-4周，胰島素樣生長因數-I濃度升高，此時較高的胰島素樣生長因數-I濃度與糖尿病緩解有關。與低分子量二元配合物的結合相比，治療後迴圈IGF-I的新增伴隨著TC含量的新增。與此變化一致，觀察到IGFBP-3的濃度也新增。囙此，當用胰島素樣生長因數-Ⅰ作為猫糖尿病生長激素狀態的標誌時，應考慮胰島素治療對胰島素樣生長因數-Ⅰ的影響。