PathophysiologyThe pathophysiology of SRR-TBIs and sport-related concussion (SRC) is multifactorial. Several mechanisms have been identified. Biomechanically, a combination of acceleration, deceleration, rotational, and translational forces directly applied or transmitted to the head affect change at the level of individual cells. Metabolic derangements, neurotransmitter dysfunction, changes in cerebral blood flood, neuroinflammation, microstructural damage, and diffuse axonal injury have all been implicated as potential pathways. Helmet-based measurement studies have attempted to quantify head impacts, providing information on force, frequency, and location. However, results vary widely among athletes diagnosed with concussions. In addition, the accuracy of the data detected by helmet sensors and video surveillance systems has been called into question; it does not necessarily reflect the impact to the brain itself, and there is no evidence to support the use of such systems to attempt to diagnose SRC.