A major depressive episode consists of depressed mood or decreased interest or pleasure most of the day, nearly every day during a 2-week period.DSM-5 has a child-specific modification allowing irritable, rather than depressed, mood to fulfill the mood criterion for a major depressive episode.Regarding duration, DSM-5 has a substantive change from DSM-IV-TR in now requiring that irritable or euphoric mood in mania/hypomania should last “most of the day nearly every day” akin to DSM-IV and DSM-5 specifications of a major depressive episode.