Lymphoid nodular hyperplasia of spleen is a benign, non-neoplastic, reactive response to an immune stimulus and frequently observed in old animals. Lymphoid nodular hyperplasia (also called grade I SFHN) composed of >70% lymphocytes with interspersed stromal/histiocytic cells; lymphocytes arranged in discrete to merging follicular structures, composed of both small and intermediate/large lymphocytes; regular presence of an outer ring of T-cells surrounding follicles. Generally, nodular hyperplasia has no negative impacts to individual’s health unless it leads to a large hematoma, which may rupture and cause hemoperitoneum. After splenectomy, the prognosis should be favorable. However, in some cases it must be differentiated from indolent lymphomas including mantle zone lymphoma and marginal zone lymphoma. Splenic indolent lymphomas in domestic animals are relatively benign neoplasms, as its name implies. In a previous study of splenic indolent lymphomas (three marginal zone lymphoma and one MCL), the patients undergo splenectomy alone and all survived more than 1 year. Nevertheless, splenic indolent lymphomas may spread to other organs in late stage. Therefore, although the current case is most likely lymphoid nodular hyperplasia, immunohistochemical stainings by using CD3 and CD79a/CD20/PAX5 can be used to confirm the diagnosis.