Dr. Christiano Sheds Light on JAK I

Dr. Christiano Sheds Light on JAK Inhibitors

Dr. Christiano recently did an audio interview about her research on JAK inhibitors for hair growth. The interview covers most of the information we’ve already heard, and also brings forth a few insightful comments from the researcher. The question that everyone still wants to know is if these JAK inhibitors could be useful for common hair loss or androgenic alopecia. Her answer was: maybe. She did say that these JAK drugs were the most efficient thing she has seen for turning on the hair follicle growth cycle in a long time, which is promising. Dr. Christiano explained that at this point it is necessary for a company with resources to move the JAK research into clinical trials. However, she made it clear that it would be fairly quick and easy to determine whether these JAK drugs were effective for hair growth during initial trials, making them a safer investment. I personally believe that a keen company, perhaps a company like Kythera, will be knocking at her door soon enough to inquire about the JAK inhibitor work. One important tidbit that I picked up from the interview is that apparently the JAK drugs need to be at a high local concentration around the hair follicle to have an effect on it’s growth. This could mean that a topical solution with enhanced permeability would be a great choice for delivery.

Finally, one thing I found interesting during the interview was that the interviewer mentioned that research on using JAK inhibitors for 3D cultured dermal papillae cells was eye opening and that he was very surprised no one was talking about it or mentioned it in the media. If you look back to my initial article, the terrific news about Tofacitinib promoting the inductivity of dermal papillae cells was highlighted and the picture of it’s results was shared.

結果 (中文) 1:

JAK 抑制剂博士克里斯蒂棚灯克里斯蒂博士最近没有音频采访关于她研究 JAK 抑制剂对头发的生长。面试时覆盖了大部分的我们已经听说过，和也带来一些精辟的见解，从研究者的信息。大家都还想知道的问题是，如果这些 JAK 抑制剂可用于常见脱发或雄激素性脱发。她的回答是: 也许。她说，这些 JAK 毒品是最有效的事，她已经在毛囊生长周期很长的时间，是有前途的车削。克里斯蒂博士解释，在这一点上需要的资源公司 JAK 研究进入临床试验。然而，她已经说明，它会相当快速，轻松地确定这些 JAK 药物是否有效的毛发生长在初步试验中，使它们更安全的投资。我个人认为，一个敏锐的公司，也许像 Kythera，公司将很快敲她的门足以打听 JAK 抑制剂工作。我捡起在采访中的一个重要珍闻是，显然 JAK 药物需要周围毛囊，对生长有影响它的局部浓度较高时。这可能意味着与增强渗透外用溶液将交付的最佳选择。Finally, one thing I found interesting during the interview was that the interviewer mentioned that research on using JAK inhibitors for 3D cultured dermal papillae cells was eye opening and that he was very surprised no one was talking about it or mentioned it in the media. If you look back to my initial article, the terrific news about Tofacitinib promoting the inductivity of dermal papillae cells was highlighted and the picture of it’s results was shared.

結果 (中文) 3:

Christiano博士揭示JAK抑制剂最近关于她的博士克里斯头发生长的JAK抑制剂研究音频采访了。访谈涵盖了我们已经听到的大部分信息，并提出了一些有见地的意见，从研究者。大家还想知道的问题是如果这些JAK抑制剂可能对常见的脱发或雄激素性脱发是有用的。她的回答是：也许。她说，这些毒品是她对JAK打开毛囊生长周期在很长一段时间看到的最有效的事，这是有希望的。Christiano博士解释说，在这一点上，它是必要的公司资源将JAK研究进入临床试验。然而，她明确表示，这将是非常快速和容易确定这些药物的有效作用对头发的生长在最初的试验中，让他们安全的投资。我个人认为，一个敏锐的公司，也许这样的公司Kythera，将敲她的门很快询问JAK抑制剂的工作。我拿起从采访中的一个重要的消息是，显然，JAK药物需要在局部高浓度毛囊周围有对其生长的影响。这可能意味着一个局部的溶液具有增强的渗透性将是一个伟大的选择交付。最后，有一件事我在采访过程中发现有趣的是，面试官提到使用JAK抑制剂的三维培养毛乳头细胞的研究是大开眼界，他很惊讶，没有人谈论它，或它在媒体中。如果你回头看看我最初的文章，关于tofacitinib促进毛乳头细胞诱导了可怕的消息和图片的结果是共享的。