With the following changes (including experimental purpose), not including new tool installation and new chemical using in process.New chemical process chemical;The modification of Chemical concentration/ purity and tool use modified material. The modification of chemical piping line/ exhaust/ drain /pumping line that contain characteristic of toxic, corrosive, flammable and combustible.The modification that increase potential of fire/explosion or reduce the design of fire protection. The modification of hardware/ material result in original safety design change.Other potential risks.(ex. Auto-loading mode transfer to manual mode, )