Primary Outcome Measures:Change in number of terminal hair follicles [的中文翻譯

Primary Outcome Measures:Change in

Primary Outcome Measures:
Change in number of terminal hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of terminal hair follicles over the treatment period.

Change in number of anagen hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of anagen hair follicles over the treatment period.

Change in number of telogen hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of telogen hair follicles over the treatment period.

Change in number of catagen hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of catagen hair follicles over the treatment period.

Change in number of vellus (vellus-like) miniaturized hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of vellus (vellus-like) miniaturized hair follicles over the treatment period.

Change in number of indeterminate hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of indeterminate hair follicles over the treatment period.


Secondary Outcome Measures:
Change in number of terminal hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in the number of terminal hair follicles over the treatment and off-treatment periods.

Change in number of anagen hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in the number of anagen hair follicles over the treatment and off-treatment periods.

Change in number of telogen hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in the number of telogen hair follicles over the treatment and off-treatment periods.

Change in number of catagen hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in the number of catagen hair follicles over the treatment and off-treatment periods.

Change in number of vellus (vellus-like) miniaturized hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in the number of vellus (vellus-like) miniaturized hair follicles over the treatment and off-treatment periods.

Change in number of indeterminate hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in the number of indeterminate hair follicles over the treatment and off-treatment periods.

Change in density of hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in density of hair follicles over the treatment and off-treatment periods.

Ratio of terminal to miniaturized hair follicles (indeterminate hair and vellus hair follicles) [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be used to determine the ratio of terminal to miniaturized hair follicles during the treatment and off-treatment
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主要观察指标:在终端毛囊数目变化 [时间框架: 基线和天 91] [指定为安全问题: 无]头皮活检获得开始治疗之前和之后 90 天的治疗将比较来确定人数的终端毛囊在治疗期间的变化。在生长期毛囊数目变化 [时间框架: 基线和天 91] [指定为安全问题: 无]头皮活检获得开始治疗之前和之后 90 天的治疗将进行比较以确定人数的生长期毛囊在治疗期间的变化。休止期的毛囊数量变化 [时间框架: 基线和天 91] [指定为安全问题: 无]头皮活检获得开始治疗之前和之后 90 天的治疗将进行比较以确定人数的休止期的毛囊在治疗期间的变化。毛发的毛囊数量变化 [时间框架: 基线和天 91] [指定为安全问题: 无]头皮活检获得开始治疗之前和之后 90 天的治疗将比较来确定人数的毛发毛囊在治疗期间的变化。毳 (毳样) 人数变化小型化毛囊 [时间框架: 基线和天 91] [指定为安全问题: 无]头皮活检获得开始治疗前和治疗 90 天后将进行比较以确定人数毳 (毳样) 毛囊在治疗期间的变化。超静定毛囊数量变化 [时间框架: 基线和天 91] [指定为安全问题: 无]头皮活检获得开始治疗之前和之后 90 天的治疗将进行比较以确定人数不定毛囊在治疗期间的变化。二次结果的措施:在终端毛囊数目变化 [时间框架: 基线、 91 天和一天 135] [指定为安全问题: 无]将对比头皮活检前开始治疗,经过 90 天的治疗,和额外的 45 天假治疗后取得过度治疗和治疗结束后时期确定终端毛囊数目的变化。在生长期毛囊数目变化 [时间框架: 基线、 91 天和一天 135] [指定为安全问题: 无]将对比头皮活检前开始治疗,经过 90 天的治疗,和额外的 45 天假治疗后取得过度治疗和治疗结束后时期确定的生长期毛囊数量的变化。休止期的毛囊数量变化 [时间框架: 基线、 91 天和一天 135] [指定为安全问题: 无]将对比头皮活检前开始治疗,经过 90 天的治疗,和额外的 45 天假治疗后取得过度治疗和治疗结束后时期确定的休止期的毛囊数量的变化。毛发的毛囊数量变化 [时间框架: 基线、 91 天和一天 135] [指定为安全问题: 无]将对比头皮活检前开始治疗,经过 90 天的治疗,和额外的 45 天假治疗后取得过度治疗和治疗结束后时期确定的毛发毛囊数量的变化。毳 (毳样) 人数变化小型化毛囊 [时间框架: 基线、 91 天和一天 135] [指定为安全问题: 无]将对比头皮活检前开始治疗,经过 90 天的治疗,和额外的 45 天假治疗后取得过度治疗和治疗结束后时期确定毳 (毳样) 毛囊数目的变化。超静定毛囊数量变化 [时间框架: 基线、 91 天和一天 135] [指定为安全问题: 无]将对比头皮活检前开始治疗,经过 90 天的治疗,和额外的 45 天假治疗后取得过度治疗和治疗结束后时期确定不确定毛囊数目的变化。在毛囊密度变化 [时间框架: 基线、 91 天和一天 135] [指定为安全问题: 无]将对比头皮活检前开始治疗,经过 90 天的治疗,和额外的 45 天假治疗后取得确定的变化在毛囊密度过度治疗和治疗结束后时期。终端对毛囊 (不定的头发和毳毛囊) 比 [时间框架: 基线、 91 天和一天 135] [指定为安全问题: 无]头皮活检前开始治疗,经过 90 天的治疗,和额外的 45 天假治疗后取得将用于治疗和治疗结束后期间确定的终端小型化的毛囊比例
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