Primary Outcome Measures:
Change in number of terminal hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of terminal hair follicles over the treatment period.
Change in number of anagen hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of anagen hair follicles over the treatment period.
Change in number of telogen hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of telogen hair follicles over the treatment period.
Change in number of catagen hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of catagen hair follicles over the treatment period.
Change in number of vellus (vellus-like) miniaturized hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of vellus (vellus-like) miniaturized hair follicles over the treatment period.
Change in number of indeterminate hair follicles [ Time Frame: Baseline and Day 91 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy and after 90 days of therapy will be compared to determine the change in number of indeterminate hair follicles over the treatment period.
Secondary Outcome Measures:
Change in number of terminal hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in the number of terminal hair follicles over the treatment and off-treatment periods.
Change in number of anagen hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in the number of anagen hair follicles over the treatment and off-treatment periods.
Change in number of telogen hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in the number of telogen hair follicles over the treatment and off-treatment periods.
Change in number of catagen hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in the number of catagen hair follicles over the treatment and off-treatment periods.
Change in number of vellus (vellus-like) miniaturized hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in the number of vellus (vellus-like) miniaturized hair follicles over the treatment and off-treatment periods.
Change in number of indeterminate hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in the number of indeterminate hair follicles over the treatment and off-treatment periods.
Change in density of hair follicles [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be compared to determine the change in density of hair follicles over the treatment and off-treatment periods.
Ratio of terminal to miniaturized hair follicles (indeterminate hair and vellus hair follicles) [ Time Frame: Baseline, Day 91 and Day 135 ] [ Designated as safety issue: No ]
Scalp biopsies obtained prior to initiating therapy, after 90 days of therapy, and after an additional 45 days off therapy will be used to determine the ratio of terminal to miniaturized hair follicles during the treatment and off-treatment