Under the simplistic assumption that cells can be represented as thin elastic layers of modulus E sitting over a rigid wavy surface with a fixed wavenumber q and an amplitude h; the ratio geff/go has been shown [26] to be larger than unity for h smaller than hcr. In other words, cell stable adhesion and, consequently, proliferation would be energetically favorable on rough surfaces as long as h < hcr, which would then identify the subset of moderately rough substrates for a given q. Also, geff/go and hcr have been predicted togrow with the normalized parameter qgadh/E