Abstract:
We investigated the reaction of alkylation of 2-phthalimido-
ethanol with ethyl chloroacetate leading to ethyl(2-phthalimi-
doethoxy)acetate. The synthesis was successfully optimised by
applying factorial design. Major side products have been
separated, identified, and characterised. The yield level was
increased from 25% to 52%, and a method of decreasing the
amount of side products has been proposed.