Elucidation of function from molecular structure is perhaps
the most exciting, but also probably the least
understood aspect of structural genomics70–73. Until
recently, only proteins with well-characterized functions
were candidates for structure determination. Structural
genomics turns that logic on its head by using the structure
to infer function.Although some basic principles
for this process have been shown to be successful, the
extent to which different approaches will prove valuable
remains to be seen.