These serious concerns have been catalysed by
the rapid increase in
carbapenemaseproducing Enterobacteriaceae
expressing enzymes such as KPC-2 (Klebsiella
pneumoniae carbapenemase-2) and NDM-1
(New Delhi metallo-β-lactamase-1).5,6 For serious
infections caused by carbapenemase-producing
Enterobacteriaceae, the treatment options are
restricted and invariably rely on tigecycline and
colistin—either singularly or in combination with
other antibiotics.7,8 Thus the global increase in
carbapenemase-producing Enterobacteriaceae has
resulted in increased use of colistin with the
inevitable risk of emerging resistance.9 This
delicate balance between