The current study involves understanding the degradation dynamics of plasmon resonant LiposAu NPs under physiological condition. It was observed that these particles were able
to degrade by the enzymatic reaction into smaller particles whose size range was ideal for renal excretion in addition to hepato-biliary route. The long-term in vivo analysis also
confirmed the bimodal clearance of these NPs. LiposAu NPs proved to be efficient candidate for in vivo photothermal mediated ablation of cancer. Their ability to generate a massive
amount of γH2A.X foci is a strong indicator of the mode of tumor ablation by DNA double strand breaks. Applicability of such novel biodegradable hybrid nanoparticle system holds great promise in cancer nanotherapeutics.