This 55-year-old male who was admitted to our ward due to cough with sputum. After admission, empirical antibiotic with Unasyn plus zithromax for infection treatment and collect sputum culture and TB culture for evaluation. The chest CT was done for evaluation due to suspect pulmonary tuberculosis, the CT showed Consider active tuberculosis(TB), with multiple cavitary lesions, centrilobular nodules and tree-in-bud branching opacifies in bilateral lungs. 2. Mediastinal lymphadenopathy. 3.Splenomegaly. He started anti-TB 4 drugs regimen HERZ from 11/27 due to sputum AFB showed positive. Skin rashes was noted and dermatologist was consulted and impressed as drug eruption and suggest to add antihistamine. Follow up blood investigations noted hyperuricemia and suggest to have more fluid intake. Patient had dizziness sometimes after anti-TB intake. Blood investigations was done after 2 weeks of anti-TB and uric acid level 12.4 and we add feburic 1#qd. We follow up AFB and 2 sets of AFB result come out still positive. We explained to the patient and continue isolation at home and continue anti-TB treatment. Today he was discharged with medications and OPD follow up 1 week later.