Simultaneous i.p. and oral (via a diet with starch containing
dough) treatment of male Black mice with sodium alginate which had
been contaminated with 85Sr 9 weeks previously, resulted in a
5-fold increase of the blood content of 85Sr. 85Sr content of
liver, kidney and spleen is increased 4-6 times by this combined
treatment. Urinary and faecal excretion of 85Sr were increased 1.2
and 1.8 times, respectively. Treatment with dietary alginate only
caused a 2.5-fold rise in blood 85Sr content, 1.5-2 times
increases of 85Sr contents in liver, spleen and kidney, a 2.1
times rise in faecal excretion of 85Sr and urinary excretion was
somewhat lowered. I.p. treatment with alginate only resulted in a
2.3-fold increase in blood 85Sr content, 2.3-3.6-fold increases of
85Sr contents of liver, spleen and kidney and a 1.7-fold increase
in urinary 85Sr excretion, while faecal excretion was not changed.
The biological half-life of Sr is about halved by the treatment with
alginate via the diet together with i.p. alginate injection.
Treatment with alginate via the diet only will speed decorporation
of Sr from skeleton by about 40% (Vanderborght et al., 1978).