The degradation study indicated that Olopatadine HCl
was susceptible to acid, base and H2O2 while it was stable
in direct sunlight and dry heat under experimental
conditions (fig. 7, 8). Olopatadine HCl gets degraded into
one to three degradation products in the stress
conditions of acid-alkali hydrolysis as well as peroxide
oxidation (fig. 4, 5, 6), while the drug showed no
degradation at 0 h in all the degradation conditions.