Functionally modified, melt-electro

Functionally modified, melt-electrospun thermoplastic polyurethane mats for wound-dressing applications.
The electrospinning of a polymer melt is an interesting process for medical applications because it eliminates the cytotoxic effects of solvents in the electrospinning solution. Wound dressings made from thermoplastic polyurethane (TPU), particularly as a porous structured electrospun membrane, are currently the focus of scientific and commercial interest. In this study, we developed a functionalized fibrillar structure as a novel antibacterial wound-dressing material with the melt-electrospinning of TPU. The surface of the fibers was modified with poly(ethylene glycol) (PEG) and silver nanoparticles (nAg's) to improve their wettability and antimicrobial properties. TPU was processed into a porous, fibrous network of beadless fibers in the micrometer range (4.89 ± 0.94 μm). The X-ray photoelectron spectroscopy results and scanning electron microscopy images confirmed the successful incorporation of nAg's onto the surface of the fiber structure. An antibacterial test indicated that the PEG-modified nAg-loaded TPU melt-electrospun structure had excellent antibacterial effects against both a Gram-positiveStaphylococcus aureus strain and Gram-negative Escherichia coli compared to unmodified and PEG-modified TPU fiber mats. Moreover, modification with nAg's and PEG increased the water-absorption ability in comparison to unmodified TPU. The cell viability and proliferation on the unmodified and modified TPU fiber mats were investigated with a mouse fibroblast cell line (L929). The results demonstrate that the PEG-modified nAg-loaded TPU mats had no cytotoxic effect on the fibroblast cells. Therefore, the melt-electrospun TPU fiber mats modified with PEG and nAg have the potential to be used as antibacterial, humidity-managing wound dressings.

結果 (中文) 1:

功能上的修改，熔体纺丝热塑性聚氨酯垫伤口敷料的应用程序。聚合物熔体纺丝是有趣的过程，为医学上的应用，因为它消除了静电纺丝溶液中溶剂的毒性影响。伤口敷料，由热塑性聚氨酯 (TPU)，特别是作为一种多孔结构化的纺膜，是目前科学和商业兴趣的焦点。在此研究中，我们开发了官能化的原纤化结构作为一种新型抗菌伤口敷料材料与 TPU 熔融纺丝。纤维的表面改性与 poly(ethylene glycol) (PEG) 和银纳米粒子 (nAg) 来提高其润湿性和抗菌性能。TPU 加工成微米 (4.89 ± 0.94 μ m) beadless 纤维多孔的纤维网络。X 射线光电子能谱和扫描电镜图像证实 nAg 表面的纤维结构的成功结合。抗菌试验表明，PEG 修饰 nAg 加载 TPU 熔体纺丝结构有良好抗菌作用反对克 positiveStaphylococcus 金黄色葡萄球菌菌株和革兰氏阴性菌大肠杆菌相比未修改 PEG 修饰 TPU 纤维毡。此外，nAg 的改性和 PEG 增加水吸收能力与未改性 TPU 相比。小鼠成纤维细胞株 (L929) 研究了细胞活性和增殖在未改性和改性 TPU 纤维毡。结果表明，PEG 修饰 nAg 加载 TPU 垫有没有对成纤维细胞的细胞毒作用。因此，熔体纺丝 TPU 纤维毡改性聚乙二醇和 nAg 有可能用作抗菌、 湿度管理伤口敷料。

結果 (中文) 3:

功能改性，熔融静电纺丝热塑性聚氨酯垫伤口敷料的应用。
对聚合物熔体静电纺丝是医疗应用的一个有趣的过程，因为它消除了溶剂纺丝液中的细胞毒作用。伤口敷料由热塑性聚氨酯（TPU），特别是作为一个多孔的静电膜，是目前科学和商业利益的焦点。在这项研究中，我们开发了一个功能化纤维结构作为一种新型的抗菌伤口敷料材料熔体静电纺丝TPU。改性的纤维表面为聚（乙二醇）（PEG）和银纳米粒子（NAG）提高其润湿性和抗菌性能。TPU加工成多孔，在微米范围内无牙口的纤维的纤维网（4.89 ± 0.94μm）。X射线光电子能谱分析和扫描电子显微镜图像证实了NAG成功掺入到纤维结构的表面。抗菌试验表明，PEG修饰的唠叨装TPU熔体静电结构具有良好的抗菌作用，对革兰氏positivestaphylococcus球菌和革兰氏阴性大肠杆菌较未改性和改性TPU纤维桩。此外，NAG和PEG修饰增加改性TPU吸水能力的比较。对未改性和改性与小鼠成纤维细胞系研究TPU纤维垫的细胞存活和增殖（L929）。结果表明，PEG修饰的唠叨装TPU垫对成纤维细胞没有细胞毒作用。因此，熔体静电TPU纤维垫和PEG修饰有NAG可作为抗菌剂的潜力，湿度管理伤口敷料。