The present study showed lignans co

The present study showed lignans could also inhibit AR protein
expression and the efficacy was similar to that of epalrestat.
Recently, it has been reported that the inhibitory effect of total lignans
from fructus arctii on aldose reductase is similar compared
to AR inhibitor epalrestat (Xu et al., 2010). This is consistent with
our findings. Moreover, lignans displayed a long-term effect of lowering
MBP. Although lignans were not comparable to captopril in
lowering MBP, they were as obvious as captopril in reversing vascular
remodeling in SHR. The findings also indicated that AR played
an influential role in the processes of hypertensive vascular remodeling.
Furthermore, AR inhibitor has been used to prevent and treat
chronic complications in diabetes. Many diabetics are subject to
hypertension. Lignans are effective fractions extracted from Eucommia
ulmoides, which has been proven to be safe and effective in
inhibiting AR and lowering blood pressure. Therefore, Eucommia
ulmoides lignans may have a great potential to treat patients subject
to both diabetes and hypertension at the same time. In addition,
we also found that both lignans and epalrestat had no effect on HR.
Captopril could reduce heart rate after being administered for 4
weeks, however, the effect of reducing heart rate became weaker
after 8 weeks. It may be related to drug tolerance.

結果 (中文) 1:

本研究表明木脂素也能抑制 AR 蛋白表达和效果是类似于依帕司他。最近，据报告，总木脂素的抑制作用从牛蒡子对醛糖还原酶是类似相比吗对抑制剂依帕司他 AR （徐等人，2010年）。这是符合我们的研究结果。此外，木脂素显示降低的远期疗效MBP。虽然木脂素并不相当于卡托普利降低 MBP，他们是卡托普利逆转血管一样明显重塑的自发性研究结果还表明 AR 演奏高血压血管重构过程中的重要作用。此外，AR 抑制剂已被用于预防和治疗在糖尿病的慢性并发症。许多糖尿病患者都是服从高血压。木脂素是从杜仲中提取的有效部位杜仲，已被证明是安全、 有效的抑制 AR 和降低血压。因此，杜仲杜仲木脂素类可能有很大的潜力来对待病人主题糖尿病和高血压，在同一时间。另外我们还发现木脂素和依帕司他并没有对人力资源的影响。卡托普利可能降低心率后管理 4几个星期，然而，降低心率的影响变弱后 8 个星期。它可能与耐药有关。

結果 (中文) 3:

目前的研究表明，木脂素也能抑制AR蛋白的表达和
的疗效是相似的，
依帕司他。近日，有报道称，相比
AR抑制剂依帕司他总木脂素
从牛蒡子对醛糖还原酶的抑制作用相似（Xu等人。，2010）。这是我们的研究结果一致
。此外，木脂素显示降低
MBP的长期影响。虽然比不上在木脂素
降低MBP卡托普利，他们在逆转血管重构
SHR卡托普利明显。研究结果也表明，AR发挥
在高血压血管重塑的过程中具有重要作用。
此外，AR抑制剂已被用于预防和治疗
糖尿病慢性并发症。许多糖尿病患者受到
高血压。木脂素是从杜仲叶中提取的有效部位
，这已被证明在
抑制AR和降血压是安全和有效的。因此，
杜仲杜仲木脂素可以治疗患者
同时糖尿病和高血压的一个巨大的潜力。此外，
我们还发现，木脂素和依帕司他对心率无影响。
卡托普利能减少心脏率给药后4
周，然而，8周后降低心率的影响逐渐减弱
。这可能是药物耐受性相关。