429. Radiother Oncol. 1985 Nov;4(3)

429. Radiother Oncol. 1985 Nov;4(3):253-63.

The assessment of early and late radiation injury to the mouse lung using X-ray
computerised tomography.

Nicholas D, Down JD.

X-ray computerised tomography (CT) was performed on the lungs of CBA and C57Bl
mice at varying time intervals after 13 and 16 Gy irradiation to the whole
thorax. With careful consideration of artefacts associated with lung
cross-sectional area and breathing rate, the mean density of the lung was
evaluated in Hounsfield units (CT number). In CBA mice, this parameter showed a
biphasic increase in lung density with time from irradiation, corresponding to an
early phase of radiation pneumonitis and a late phase dominated by pleural
effusions. Reduced lung volumes were also seen during the late response and lung
compression due to accumulations of pleural fluid is considered a major factor in
these observations. C57Bl mice did not develop radiation pneumonitis but appeared
to be equally responsive to later radiation-induced increases in lung density.
The results obtained from CT-derived densitometry compared well with measurements
gained from functional and survival endpoints. X-ray CT provides a sensitive and
informative technique for assessing the extent of radiation injury to the mouse
lung and is potentially useful for quantifying the counterpart in patients.

PMID: 4081113 [PubMed - indexed for MEDLINE]

結果 (中文) 1:

429.Radiother Oncol。1985 Nov; 3:253 63。早期和晚期的辐射损伤小鼠肺使用 x 射线进行评估电脑断层扫描。尼古拉斯 · D，JD 下来。X 射线计算机断层扫描 (CT) 进行的 CBA 与 C57Bl 肺在不同的时间间隔向全体 13 和 16 Gy 照射后小鼠胸部。仔细考虑与肺癌相关的文物截面积和呼吸率，肺的平均密度是在豪森菲尔德单位 （CT 数） 的评价。CBA 在小鼠中，此参数显示双相增加肺密度与从辐照，对应的时间放射性肺炎和由胸腔的后期阶段的早期阶段积液。减少的肺容量也被迟了回应和肺期间由于积累的胸腔积液压缩被认为是主要因素这些意见。C57Bl 小鼠急性放射性肺损伤的发展也并不但是出现要稍后辐射诱导肺密度增加同样的反应。从源性 CT 密度好相比测量获得的结果获得从功能和生存终结点。X 射线 CT 提供了一种敏感和信息技术的评估对小鼠辐射损伤的程度肺和量化患者对应可能有用。PMID: 4081113 [PubMed-索引为 MEDLINE]

結果 (中文) 3:

429。放疗，可杂志。1985年11月；4（3）：253—63。评价早期和晚期辐射the to the鼠标肺损伤用X射线computerised tomography。唐氏Nicholas d，JD。X射线（CT）是computerised tomography Performed CBA和C57BL lungs on the of时间在变intervals小鼠后13和16 Gy辐照to the Wholethorax。与artefacts与肺腺consideration小心of的跨截面面积的呼吸速率和平均肺密度，was the of the在evaluated豪森菲尔德units（CT值）。在CBA小鼠，这给在参数在biphasic增加肺密度与辐照时间from，to an对应早期和晚期阶段的辐射模式相pneumonitis pleural占优effusions。我也看到在volumes降肺反应和肺末茶压缩流体accumulations pleural is to学院两个专业的事情考虑因子这些观察。C57BL小鼠pneumonitis did not but appeared辐射源一equally to be to increases辐射诱导反应在肺密度。结果CT源性obtained from the densitometry compared阱与测量从海外的功能和生存的端点。在X射线CT提供敏感和信息技术职业评估辐射损伤extent of the to the鼠标肺和is useful for the counterpart«potentially患者。pmid：PubMed MEDLINE indexed for 4081113 [ - ]