allow RCM macrocyclization with mai

allow RCM macrocyclization with maintenance of the critical
‘P3T4A5P6’ recognition region. By employing a range of chain
lengths in the N-alkenyl side chains, a series of macrocycles (1–
4) could be constructed that would vary in ring size and location
of ring-closure attachments (Fig. 1). In this fashion, we could explore
a variety of macrocycle structures in an attempt to arrive
at optimum configurations. A similar generation of libraries of
macrocyclic peptides has previously been described as an approach
at interrogating bioactive conformations.

結果 (中文) 1:

允许 RCM macrocyclization 与维护的关键'P3T4A5P6' 识别区域。通过采用一系列链在 N-烯基侧链的一系列的大环化合物 (1 – 长度4) 无法建造，将中环的大小和位置会发生变化开环和闭环附件 (图 1)。以这种方式，我们可以探讨各种大环结构，试图到达在优化配置。图书馆一类似代大环肽以前被描述为一种方法在审问生物活性构象。

結果 (中文) 3:

允许的临界维修RCM macrocyclization“p3t4a5p6识别区。通过采用一系列的链在异戊烯基侧链的长度，一系列的大环（1–4）可以构建不同的环的大小和位置密封环附件（图1）。在这种方式中，我们可以探索在尝试到各种大环结构在最佳配置。类似一代图书馆大环肽已被描述为一个方法在对具有生物活性的构象。