摘要 目的 探讨妊娠期胆汁淤积症（lCP)患者临床特点及胎盘病理学改变

摘要 目的 探讨妊娠期胆汁淤积症（lCP)患者临床特点及胎盘病理学改变，旨在提高临床医生对ICP的认识，指导治疗。方法 收集我院2012年1月～2013年12月住院分娩的孕妇及确诊的ICP患者的临床及胎盘病理学资料，进行回顾性分析。结果 分娩的孕妇5191例，符合ICP诊断标准的孕妇176例，平均发病率3.39%，经产妇28.41%，多胎6.82%，剖宫产率80.11%，ICP的发病高峰年龄在25岁～30岁，占46.59%，剖宫产率48.86%，孕37周前，病例组和正常组的胎盘病理形态学前六项指标的变化，有显著性差异（P0.05）。结论 本地区是ICP的高发区，高发年龄25～30岁，高危期在孕33～37周，ICP患者的胎盘呈过度成熟及老化，是导致宫内胎儿窒息及死亡的病理学基础。
关键词 妊娠；肝内胆汁瘀积症；临床特点；胎盘；病理形态学

結果 (中文) 1:

摘要 目的 探讨妊娠期胆汁淤积症（lCP)患者临床特点及胎盘病理学改变，旨在提高临床医生对ICP的认识，指导治疗。 方法 收集我院2012年1月～2013年12月住院分娩的孕妇及确诊的ICP患者的临床及胎盘病理学资料，进行回顾性分析。 结果 分娩的孕妇5191例，符合ICP诊断标准的孕妇176例，平均发病率3.39%，经产妇28.41%，多胎6.82%，剖宫产率80.11%，ICP的发病高峰年龄在25岁～30岁，占46.59%，剖宫产率48.86%，孕37周前，病例组和正常组的胎盘病理形态学前六项指标的变化，有显著性差异（P<0.05）， 而孕37周及孕40周以上，无统计学意义（P>0.05）。 结论 本地区是ICP的高发区，高发年龄25～30岁，高危期在孕33～37周，ICP患者的胎盘呈过度成熟及老化，是导致宫内胎儿窒息及死亡的病理学基础。关键词 妊娠；肝内胆汁瘀积症；临床特点；胎盘；病理形态学

結果 (中文) 3:

Objective to investigate the clinical characteristics and pathological changes of placenta in patients with pregnancy induced cholestasis (lCP), and to improve the understanding of ICP, and to guide the treatment. Methods to collect the clinical and pathological data of patients with ICP in our hospital from December 2013 to January 2012, and to analyze the clinical and pathological data of placenta. Results 5191 pregnant women, 176 cases of pregnant women in accordance with ICP diagnostic criteria, the average incidence rate of 3.39%, 28.41%, 6.82%, 80.11%, 30, ICP, 25, 46.59%, 48.86%, 37 weeks after birth,There were significant differences in the changes of the six indicators of the pathological changes of the placenta in the case group and the normal group (P<0.05), while the 37 weeks and 40 weeks of pregnancy were not statistically significant (P>0.05). Conclusion the local area is a high risk area of ICP, the high risk age is 30 to 33 years old, and the high risk period is 25 to 37 weeks, the ICP patient's placenta is over mature and aging, which is the pathological basis of intrauterine fetal asphyxia and death. Keywords pregnancy; intrahepatic cholestasis; clinical characteristics; placenta; pathological morphology.