Sortilin is a newly identified member of a small family of proteins characterized to contain a Vps10p domain. Sortilin can function alone or as part of a co-receptor as well as a transporter of proteins from the trans-Golgi network (TGN).As a co-receptor of p75 neurotrophin receptor (p75NTR), sortilin binds the immature, pro-forms of nerve growth factor (NGF) or brain derived