Oral administration of uncoated tab

Oral administration of uncoated tablet (TH-Lac) reduced the maximum concentration (Cmax) from 21.15 ± 1.99 to 14.79 ± 1.36 µg/mL. Oral administration of coated tablet (TH-Lac-A50) further reduced the maximum concentration to 8.93 ± 1.91 µg/mL, and the time to reach Cmax was postponed from 3.40 ± 0.55 to 13.60 ± 1.67 hr. The mean residence time (MRT) was prolonged from 11.25 ± 1.47 to 15.65 ± 1.72 hr after oral administration of coated tablets, but there was no significant difference in AUC between coated and uncoated tablets.

結果 (繁體中文) 1:

未包衣片劑（TH-LAC）的口服給藥從21.15±1.99減少的最大濃度（Cmax）至14.79±1.36微克/毫升。包衣片劑的口服給藥（TH-紫膠-A50）進一步的最大濃度減少到8.93±1.91微克/毫升，以及達到C max的時間從3.40±0.55推遲至13.60±1.67小時。的平均停留時間（MRT）是從11.25±1.47延長至15.65±1.72小時包衣片劑的口服給藥後，但有在AUC塗佈和未塗佈的片劑之間沒有顯著差異。

結果 (繁體中文) 2:

口服無塗層片劑（TH-Lac）將最大濃度（Cmax）從21.15 ±1.99降至14.79~1.36微克/升。塗布片劑（TH-Lac-A50）的口服進一步將最大濃度降至8.93 ~1.91微克/升，到達Cmax的時間從3.40±0.55降至13.60±1.67小時。口服塗布片劑後的平均停留時間（MRT）從11.25~1.47延長到15.65~1.72小時，但塗層片劑和無塗層片劑在AUC+中無顯著差異。

結果 (繁體中文) 3:

口服未包衣片（TH-Lac）可將最大濃度（Cmax）從21.15±1.99降低到14.79±1.36μg/mL。口服包衣片（TH-Lac-A50）可將最大濃度進一步降低到8.93±1.91μg/mL，達到Cmax的時間從3.40±0.55延后到13.60±1.67小時。口服包衣片後平均停留時間（MRT）由11.25±1.47小時延長到15.65±1.72小時，但包衣片與未包衣片的AUC無顯著性差异。