Decreased abundance of the active nuclear fragment was originally reported by Peterson et al. (2004) in mammary cell culture, and transcriptional downregulation of SREBF1 in vivo was reported by Harvatine and Bauman (2006a) and subsequently verified by others (e.g., Gervais et al., 2009; Han et al., 2012; Vyas et al., 2013). Li et al. (2014) reported that overexpression of sterol response element transcription factor 1 (SREBF1) increased milk fat and inhibition decreased milk fat in bovine mammary epithelial cell culture and Ma et al. (2014) reported that trans-10,cis-12 conjugated linoleic acid (CLA) inhibited a reporter construct that contained the Sterol regulatory element-binding protein (SREBP) response element.