A simple framework to guide the management of a delirious patient is “Stop, THINK, and lastly medicate.” This framework directs our focus and attention to identifying etiology first, before moving toward pharmacological strategies. Delirium in the ICU is often multifactorial, and determining causation can be complicated. Evaluate the patient’s medications and stop (or lower the dose of) any medications known to cause delirium. The 2013 PAD guidelines recommend against using benzodiazepines for sedation unless otherwise indicated for situations like alcohol or benzodiazepine withdrawal.