The change in the directed Granger information flow fromthe lAMY
to the lINS from the up-regulation to the down-regulation condition
was also positively correlated (r=0.27, p=0.028)with the brain activity
in the lINS (Fig. 4b). That is, the stronger the increase in directed
Granger information flow from the lINS to the rINS, the less activity
was observed at lINS in the up-regulation condition.Moreover, a significant
negative correlation (r = −0.32, p = 0.009) was observed between
the causality change in this direction from down-regulation to
up-regulation and the brain activity of the lINS