BC has been produced with different morphologies depending on the bacterial strain, addition of some components to the medium, growing conditions, and drying methods [228]. Different authors have taken advantage of this fact to create BC with a desired morphology. For example, Zang and Sun [229] restricted the movement of bacteria through a platform with microgrooves and oxygenbubbles. They obtained a BC scaffold with the structure of grid and strip that could have potential interest for the preparation of scaffolds in the biomedical field. In addition, Bodin and Backdahl [230] made bacteria grow in oxygenated silicon tubes, allowing the formation oftubular shaped BC that can be used as a digestive tract and vascular grafts.Once BC is produced, it can be easily modified by coatings or chemical methods like grafting [231].However, the in situ modification of BC during its culture is becoming more relevant as a way of modifying some of its properties in its early stages of production by the addition of the required component [232].