MATERIALS AND METHODS: Thirty-two W

MATERIALS AND METHODS: Thirty-two Wistar rats were divided into four groups. The
rats in Group 1 received melatonin and underwent radiation therapy. The rats in
Group 2 received no melatonin and underwent radiation therapy. The rats in Group
3 received melatonin and underwent sham radiation therapy. The rats in Group 4
received no melatonin and underwent sham radiation therapy. Melatonin was
administered at a dose of 100 mg/kg using an intraperitoneal injection. Radiation
therapy was delivered on a Cobalt-60 unit using a single fraction of 18 Gy
through an anterior portal covering the right lung in entirety. The rats
underwent euthanasia at 6 weeks following radiation therapy. The lungs were
dissected and blinded histopathological evaluation was performed.
RESULTS: Concerning the right lung, a decrease in intra-alveolar edema and
intra-alveolar erythrocytes was observed despite an increase in activated
macrophages, intra-alveolar fibrosis, hyaline arteriosclerosis and alveolar wall
thickness for the rats in Group 1 as compared to the rats in Group 2. Concerning
the left lung, a decrease in alveolar neutrophils and intra-alveolar erythrocytes
was evident despite an increase in activated macrophages, hyaline
arteriosclerosis and alveolar wall thickness for the rats in Group 1 as compared
to the rats in Group 2.
CONCLUSIONS: This study puts forward the histopathological evidence regarding the
effectiveness of melatonin as a protectant against acute lung injury induced by
radiation therapy through restrained inflammation, regrettably at the expense of
promoted fibrosis. The effectiveness of melatonin as a protectant against acute
lung injury induced by radiation therapy needs to be evaluated further for the
unresolved concerns regarding the safety.

結果 (中文) 1:

材料和方法︰ 三十二 Wistar 大鼠分为四个组。的在第 1 组大鼠收到褪黑激素，并接受放射治疗。在大鼠2 组收到没有褪黑激素和接受放射治疗。组大鼠3 收到褪黑激素和深水辐射治疗。4 组大鼠收到不褪黑激素和深水辐射治疗。褪黑激素是在 100 毫克/公斤腹腔注射剂量进行管理。辐射治疗被交付使用 18 Gy 单分数的钴-60 单位通过前的门户覆盖整个右肺。大鼠术后放射治疗 6 周时安乐死。肺是进行了解剖和盲法的组织病理学评价。结果︰ 关于右肺，跌幅肺泡腔水肿和肺泡腔红细胞与会者尽管增加激活巨噬细胞、 肺泡纤维化、 透明动脉硬化和肺泡壁比较 2 组大鼠在第 1 组大鼠的厚度。关于左的肺，肺泡中性粒细胞和肺泡腔红细胞减少很明显尽管增加活化巨噬细胞，透明在第 1 组相比，大鼠动脉粥样硬化和肺泡壁厚对 2 组大鼠。结论︰ 本研究提出了组织病理学证据关于褪黑激素作为保护剂对诱导的急性肺损伤的有效性放射治疗通过抑制炎症，遗憾的是牺牲了促进纤维化。褪黑激素作为保护剂对急性的有效性放射治疗所致的肺损伤需要被评估为进一步关于安全问题未解决的疑虑。

結果 (中文) 3:

材料和方法：三零二只Wistar大鼠随机分为四组。这个1组大鼠接受褪黑激素，并接受放射治疗。大鼠组2例无褪黑素，接受放射治疗。组大鼠3接受褪黑激素，并接受假放射治疗。4组大鼠无褪黑激素和接受假放射治疗。褪黑素是使用腹腔注射的剂量为100毫克/公斤。辐射治疗上采用18 Gy单成分钴-60单位交付通过一个完整的右肺前入口。大鼠接受安乐死在6周后，放射治疗。肺解剖和双盲进行组织病理学评价。结果：关于右肺，肺泡内水肿和肺泡内水肿的减少观察肺泡内的红细胞，尽管激活增加巨噬细胞，肺泡内纤维化，玻璃样硬化和肺泡壁1组大鼠的厚度相比，在第2组。有关左肺，肺泡内嗜中性粒细胞和肺泡内红细胞减少尽管在活化的巨噬细胞明显增加，透明1组大鼠动脉硬化和肺泡壁厚度的比较对2组大鼠。结论：本研究提出了有关的组织病理学的证据褪黑素作为对抗性诱导的急性肺损伤的保护剂通过抑制炎症的放射治疗，令人遗憾的是，在促进纤维化。褪黑激素的有效性作为保护剂对急性放射治疗引起的肺损伤需要进一步评估关于安全的未解决的担忧。