As a systematic process to change the launching, implementation and sustainability oriented of enterprise strategy and a powerful tool to gain sustainable competitive advantage for the enterprise, strategic change is according to variety changes that may occur or had occurred within the external or internal environment; It follows the dynamics of coordination principles among environment, strategy and organizational; It refers to simultaneous support changes of the elements of organization. Abandoning the old concepts, which faces resistances that come from the management layers, staffs, stakeholders and the lag cultures, is the key of strategic changes. Top managers facing changes appear to be very hesitant even if they recognize the influences from new ideas and strategies. In reality, only few enterprises succeeded in strategic changes while the others failed. Human resource managers, strategic partners of the enterprise, should figure out appropriate strategies to solve the problems associated with organizational changes. Resource-dependent of strategy determines that the content of resources and the changes of resources mix which have significant impact on enterprise's strategy. Human resource managers can allocate and integrate resources which play a key role in strategic change by following a certain approach; by doing so, they can achieve the matching of resources and strategies.