Even as structural genomics provide

Even as structural genomics provides a solid foundation
for the future of structural biology research, its
limitations leave much exciting work to be done.
Improvements in sequence analysis100 and comparative
modelling will yield disproportionate enhancements in
the number and quality of modelled structures.
Likewise, building from the repertoire of known structures,
computational methods using limited experimental
data101–103 and ab initio approaches104 should
help to fill in knowledge of domains beyond the
resources of fully experimental approaches. The technology
developed for structural genomics is also
expected to provide a watershed for studies of those
macromolecules not suited for high-throughput studies,
by providing the means to rapidly explore several
expression constructs and screen through many purification
and crystallization protocols. It will also allow
for parallel studies of homologues, such as all human
kinases, to understand their specificity. In addition,
structural genomics will provide a platform for detailed
studies on molecular dynamics and interactions105, and
for the elucidation of large macromolecular complexes
by X-ray crystallography and electron microscopy106. In
this way, even as structural genomics brings our knowledge
of protein-domain structures near to completion,
it is a prelude to a still richer knowledge of molecular
structure and function.

結果 (中文) 1:

甚至像结构基因组学提供了坚实的基础未来的结构生物学研究，其局限性离开多令人兴奋的工作要做。改进的序列 analysis100 和比较模型将产生不成比例的增强功能数量和质量的模型结构。同样，建筑从已知结构，汇辑计算方法采用有限的实验data101 — — 103 和 ab 从头 approaches104 应要填写的域之外的知识的帮助资源的充分实验方法。技术开发结构基因组学是也是预计为这些研究提供一个分水岭大分子不适合高通量研究通过提供手段迅速探讨几个表达式构造和屏幕通过许多净化和结晶协议。它还将使同系物，等所有人的平行研究激酶，了解其特异性。另外结构基因组学将会提供一个平台，为详细分子动力学和 interactions105，研究和为澄清这种大型的大分子复合物通过 x 射线晶体学和电子 microscopy106。在这种方式，甚至作为结构基因组学带来了我们的知识蛋白质域结构接近完成，它是前奏的分子仍然丰富的知识结构和功能。

結果 (中文) 3:

即使结构基因组学提供了坚实的基础未来结构生物学研究限制留下令人兴奋的工作要做。在序列analysis100对比改进建模将产生不成比例的增强模拟结构的数量和质量。同样，从已知结构的剧目，有限实验的计算方法data101–103和从头approaches104应该帮助填写领域以外的知识充分实验方法资源。技术发展为结构基因组学也是期望为这些研究提供一个分水岭不适合高通量研究的大分子，通过提供手段，快速探索几个表达结构和筛选通过许多纯化和结晶协议。它也将允许对于同系物的平行研究，如所有人类激酶，了解它们的特异性。此外,结构基因组学将提供详细的平台分子动力学和interactions105研究和大分子复合物的阐明通过X射线衍射和电子microscopy106。在这样，即使结构基因组学带来了我们的知识蛋白质结构域接近完成，这是一个更丰富的分子知识的前奏结构与功能。