415. Radiat Res. 1990 Apr;122(1):95

415. Radiat Res. 1990 Apr;122(1):95-100.

Kidney and lung injury in irradiated rats protected from acute death by
partial-body shielding.

Geraci JP(1), Jackson KL, Mariano MS, Michieli BM.

Author information:
(1)Department of Environmental Health, School of Public Health and Community
Medicine, University of Washington, Seattle 98195.

Ninety-six CD-1 male rats were exposed to gamma-ray doses (0-25 Gy) in increments
of 5 Gy. One femur, the surgically exteriorized GI tract, and the oral cavity
were shielded during irradiation to protect against acute mortality from injury
to the hematopoietic system, small intestine, and oral cavity. In addition, the
thoraxes of half of the animals from each dose group were shielded. At
approximately monthly intervals from 2 to 10 months after irradiation the
hematocrit, plasma urea nitrogen (PUN), and 51Cr-EDTA clearance were measured.
During the study 20 thorax-shielded and 19 thorax-irradiated animals died. All
rats whose thoraxes received 25 Gy irradiation and three out of seven rats whose
thoraxes received 20 Gy died 1 to 3 months postirradiation with massive pleural
fluid accumulation. Shielding the thoraxes prevented this mode of death at these
doses. Kidney injury was judged to be the primary cause of death of all
thorax-shielded animals and 15- and 20-Gy thorax-irradiated animals. Animals with
kidney damage had elevated PUN and reduced 51Cr-EDTA clearance and hematocrits.
The relative merits of each of these end points in assessing radiation-induced
kidney injury after total-body exposure are discussed.

PMID: 2108469 [PubMed - indexed for MEDLINE]

結果 (中文) 1:

415.辐射 res.1990 Apr; 1:95-100。保护从急性死亡的辐照大鼠的肾和肺损伤身体部分屏蔽。热拉西 JP(1)，杰克逊 KL，马里亚诺 · MS Michieli BM。作者信息︰(1)环境卫生、 公共卫生学院和社区部医学，华盛顿大学西雅图 98195。百分之九十六 CD 1 雄性大鼠被暴露了伽玛射线剂量 (0-25 Gy) 增量5 Gy。一个股骨、 手术肉身的胃肠道和口腔内被屏蔽期间辐照以防止急性死亡率从损伤对造血系统、 小肠和口腔。此外，胸部的一半从各剂量组动物被屏蔽。在大约每月间隔时间从 2 到 10 个月后照射红细胞压积、 血浆尿素氮 （双关） 和 51 铬 EDTA 间隙进行了测定。在研究期间 20 胸部屏蔽和 19 的胸部照射动物死亡。所有老鼠的胸部收到 25 Gy 照射和七分之三的大鼠谁胸部收到 20 Gy 死了 1 至 3 个月 postirradiation 与大量胸腔积液。屏蔽胸部阻止这种模式在这些死亡的剂量。肾损伤被认为是所有死亡的主要原因胸部屏蔽动物和 15 和 20 Gy 胸部照射动物。与动物双关和减少 51 铬-EDTA 间隙和血细胞比容升高肾损害。每个这些终结点在评估辐射诱导的相对优点讨论了全身暴露后的肾损伤。PMID: 2108469 [PubMed-索引为 MEDLINE]

結果 (中文) 3:

415。辐射RES。1990年4月；122（1）：95～100。肾与肺损伤大鼠急性照射protected from death by身体部分屏蔽。geraci JP（1），杰克逊吉隆坡，马里亚诺MS，michieli BM。作者信息：（1）环境卫生部，公共卫生学院和社区医学，华盛顿大学西雅图98195。九十个CD-1雄性大鼠were exposed toγ射线剂量（0～25 Gy）在incrementsof 5 Gy。一个手术exteriorized股骨，胃肠道，口腔and thewere during to protect against保护照射急性死亡率从损伤to the造血系统、小肠和口腔。此外，the胸部of half of the animals from each剂量集团是保护。at约每月10个月后间隔从2 to the照射hematocrit血浆尿素氮（双关语），51Cr EDTA和清除被仔细测量了。during the Study and 19 20胸部保护胸部照射动物死了。All25 Gy照射大鼠的胸received and three out of seven老鼠的胸部received 20 Gy死1至3个月postirradiation以及大量积液流体的积累。屏蔽the胸部prevented of Death at these这模式剂量。肾损伤的主要原因是以to be the of death of all胸部保护动物和15和20 Gy照射动物的胸部。动物以及肾损伤有不同的双关语的51Cr EDTA and reduced间隙和hematocrits。the相对of each of these结束点需要在评估辐射诱导肾损伤后总的身体接触都进行了讨论。pmid：2108469 [索引] for Medline PubMed -