The TP63 gene and all its protein isoforms serve pleiotropic
functions encompassing nearly all aspects of cellular life.
The scientific community recognized early the importance
of discerning between different p63 isoforms, thus facilitating
the study of functions specific to each class of protein.
Still, we are only at the tip of the iceberg. Genetic studies in
mice have shed much light on the roles of TAp63 versus
ΔNp63 isoforms in development and adult epithelial