Figure 1 | The writer, eraser and reader proteins of m6A. The deposition, removal and recognition of N6-methyladenosine (m6A) are carried out by cognate factors termed writers, erasers and readers, respectively. Mammalian m6A writers function as a protein complex with four identified components so far:methyltransferase-like 3 (METTL3), METTL14, Wilms tumour 1‑associated protein (WTAP) and KIAA1429. Two m6A erasers have been reported: fat mass and obesity associated protein (FTO) and alkB homologue 5 (ALKBH5). The function of m6A is
mediated partly by reader proteins, which have been identified in members of the YT521‑B homology (YTH) domain-containing protein and the heterogeneous nuclear
ribonucleoprotein (HNRNP) protein families.