Among the antibodies most common and characteristic of the severe form of SSc (diffuse cutaneous SSc, dcSSc)are antibodies to DNA topoisomerase I, also known as Scl-70. Several respondents indicated that they wouldreport this patient as having an antibody to Scl-70. Recently, Andrade and colleagues1 described in detail theHEp-2 cell staining pattern caused by anti-Scl-70 antibodies. Typical staining characteristics are: