A mouse with replaceable push panel, comprising a push panel and a base unit, the base unit including therein an embedding unit defining a trough, and having a check unit portion adjacent the trough; the push panel detachably overlaying an upper portion of the base unit, the push panel including a fastening key projecting therefrom to pass through the trough of the embedding unit, the fastening key terminating at a fastening unit portion engaging the check unit portion in releasably locked manner, whereby the push panel is assembled onto and disassembled from the base unit in user selective manner.