Disgust for contaminating objects (core disgust), immoral behaviors (moral disgust) and unsavory others (interpersonal disgust), have been assumed tobe closely related. It is not clear, however, whether different forms of disgust are mediated by overlapping or specific neural substrates. We report that10 patients with damage to the ventromedial prefrontal cortex (vmPFC) avoided behaviors that normally elicit interpersonal disgust (e.g. using the scarfof a busker) less frequently than healthy and brain-damaged controls, whereas they avoided core and moral disgust elicitors at normal rates. Theseresults indicate that different forms of disgust are dissociated neurally. We propose that the vmPFC is causally (and selectively) involved in mediatinginterpersonal disgust, shaping patterns of social avoidance and approach.