Abstract: lomerizine is a new two phenyl piperazine derivatives of calcium antagonists, which belongs to the third generation of piperazine cerebral vasodilator, on cerebrovascular more selective, increase cerebral blood flow, brain protection effect is stronger, the effects of heart is small, so the better curative effect, less adverse reaction.For the preventive treatment of migraine.In this paper, lomerizine synthesis was studied.Key words:
Lomerizine Hydrochloride, synthesis, migraine
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