Although Fe@Au nanoparticles show a similar cancerpreferential
cytotoxicity in colorectal cancers (CRC), it
seems that CRC is much more resistant to Fe@Au treatment,
compared with oral cancer cells.
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However, the underlying
mechanism of CRC resistance to the Fe@Au treatment is
still unclear. Unraveling the puzzle of differential responses
different cancer types to Fe@Au treatment should lead to
more efficient anticancer strategies in the future. Therefore,
the research presented here aims to investigate the differential
response of CRC to Fe@Au treatment. We first investigated
the underlying molecular mechanisms of the cytotoxicity
induced by Fe@Au in CRC and then explored the role of different
elements in anticancer properties that we observed.