Extraction is the first and crucial step for studying the natural antioxidants from plants (Figure 1). Many extraction factors play important roles in the extraction efficiency, such as type and concentration of extraction solvent, extraction temperature, extraction time, and extraction pH. Among them, the solvent is one of the most influential factors. Numerous solvents have been used for the extraction of antioxidants from food and medicinal plants. The selection of solvents is based on the chemical nature and polarity of antioxidant compounds to be extracted. Most of the phenolics, flavanoids and anthocyanins are hydrosoluble antioxidants. The polar and medium polar solvents, such as water, ethanol, methanol, propanol, acetone and their aqueous mixtures, are widely used for extraction [32,33,34,35]. Carotenoids are lipid-soluble antioxidants, and common organic solvents, such as the mixtures of hexane with acetone, ethanol, methanol, or mixtures of ethyl acetate with acetone, ethanol, methanol, have been used for extraction [36,37,38].