Venlafaxine is an antidepressant and, like many neuroactive agents, it is an amine-alcohol, in this case, the two functional groups are i,3-related, so we aim to use a 1,3-did disconnection. Usually,you would convert the amine
to an alcohol to simplify the disconnection, but饰spotting the oppor-
tunity far using a nitrite you can
N-Me groups is necessary.
avoid the need for this extra step. A preliminary removal of the two N-Me groups is necessary.