The American Association of Diabetes has emphasized on the importance of blood sugar control in diabetic patients and considers nurses’ function essential in successful administration of protocols, taking medical orders, precise monitoring, and educational programs of blood sugar control.[14] Outcomes of hyperglycemia control through insulin infusion compared to conventional methods have been considered in various studies. Among these outcomes, mean blood sugar level at the time of beginning insulin infusion[15] and the level of hypoglycemia[11,13,15]can be mentioned. As the conventional method in CCUs in Iran is usage of a subcutaneous insulin injection chart as well as insulin infusion in acute period of the disease to achieve the aforementioned outcomes better and faster, the present study compared the effects of insulin infusion method to those of conventional method (subcutaneous insulin injection) on blood sugar control and the outcomes such as hypoglycemia, and on achieving the target blood sugar in diabetic patients with acute coronary syndrome in CCUs.