As the disease progresses, patients are compelled to cope with physical symptoms that develop one after another. Faced with these circumstances, caution is required when dealing with patients during this phase, when they are also often confronted with situations that may make the cure of their disease difficult. Because many patients are trying to concentrate on treatment during the phase, with the aim of a cure, the improvement of physical functions is often ranked first among patient’s hopes with regard to rehabilitation. However, when they approach the transition period, it becomes necessary to consider what it is that they really want to do in anticipation of the future deterioration of their physical condition. It takes time for this transition to occur, and the feelings of patients and their families may change markedly. It is important to recognize that fluctuating feelings are natural, and it may be necessary to listen closely to the patients and their families from time to time and await their choices. In terms of the goals of rehabilitation, the rehabilitation staff should interact with the patients and their families in a manner that will enable them to accept reality and to identify their goals. The rehabilitation approach should also take into consideration the environment surrounding the patient, including the patients’ own remaining functional activities as well as the human support that is available, the utilization of healthcare devices, and the utilization of social resources, so that patients are able to achieve whatever they hope to do.